Research Interest
1. Neurogenesis in the adult and developing brain.
I focus on new neurons that are continually generated throughout adulthood in predominantly two regions of the brain, especially, the subgranular zone (SGZ) of the dentate gyrus in the hippocampus.
2. Application of bioactive compounds from Thai plants in biomedical research.
I am interested in the antioxidant effect of Thai plants on neural stem cells in the hippocampal dentate gyrus that is associated with memory, anti-aging and anti-cancer.
Publications
Sritawan N, Sirichoat A, Aranarochana A, Pannangrong W, Wigmore P, Welbat JU. Protective effect of metformin on methotrexate induced reduction of rat hippocampal neural stem cells and neurogenesis. Biomed Pharmacother. 2023; 162: 114613.
Sirichoat A, Anosri T, Kaewngam S, Aranarochana A, Pannangrong W, Wigmore P, et al. Neuroprotective properties of chrysin on decreases of cell proliferation, immature neurons and neuronal cell survival in the hippocampal dentate gyrus associated with cognition induced by methotrexate. Neurotoxicology. 2022; 92: 15-24.
Suwannakot K, Sritawan N, Naewla S, Aranarochana A, Sirichoat A, Pannangrong W, et al. Melatonin attenuates methotrexate-induced reduction of antioxidant activity related to decreases of neurogenesis in adult rat hippocampus and prefrontal cortex. Oxid Med Cell Longev. 2022; 22: 13.
Saenno R, Dornlakorn O, Anosri T, Kaewngam S, Sirichoat A, Aranarochana A, et al. Caffeic Acid Alleviates Memory and Hippocampal Neurogenesis Deficits in Aging Rats Induced by D-Galactose. Nutrients. 2022; 14(10): 2169.
Aranarochana A, Kaewngam S, Anosri T, Sirichoat A, Pannangrong W, Wigmore P, et al. Hesperidin Reduces Memory Impairment Associated with Adult Rat Hippocampal Neurogenesis Triggered by Valproic Acid. Nutrients. 2021; 13(12): 4364.
Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU. Melatonin Ameliorates Valproic Acid-Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats. Oxid Med Cell Longev. 2021; 9997582.
Sritawan N, Suwannakot K, Naewla S, Chaisawang P, Aranarochana A, Sirichoat A, et al. Effect of metformin treatment on memory and hippocampal neurogenesis decline correlated with oxidative stress induced by methotrexate in rats. Biomed Pharmacother. 2021; 144: 112280.
Suwannakot K, Sritawan N, Prajit R, Aranarochana A, Sirichoat A, Pannangrong W, Wigmore P, et al. Melatonin protects against the side-effects of 5-fluorouracil on hippocampal neurogenesis and ameliorates antioxidant activity in an adult rat hippocampus and prefrontal cortex. Antioxidant. 2021; 10: 615.
Sritawan N, Prajit R, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, et al. Metformin alleviates memory and hippocampal neurogenesis decline induced by methotrexate chemotherapy in a rat model. Biomed Pharmacother. 2020; 131: 110651.
Welbat JU, Naewla S, Pannangrong W, Sirichoat A, Aranarochana A, Wigmore P. Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat. Biochem Pharmacol. 2020; 178: 114083.
Sirichoat A, Suwannakot K, Chaisawang P, Pannangrong W, Aranarochana A, Wigmore P, et al. Melatonin attenuates 5-fluorouracil-induced spatial memory and hippocampal neurogenesis impairment in adult rats. Life Sci. 2020; 248: 117468.
Prajit R, Sritawan N, Suwannakot K, Naewla S, Aranarochana A, Sirichoat A, et al. Chrysin protects against memory and hippocampal neurogenesis depletion in D-galactose-induced aging in rats. Nutrients. 2020; 12: 1100.
Sirichoat A, Krutsri S, Suwannakot K, Aranarochana A, Chaisawang P, Pannangrong W, et al. Melatonin protects against methotrexate-induced memory deficit and hippocampal neurogenesis impairment in a rat model. Biochem Pharmacol. 2019; 163: 225-233.
Aranarochana A, Chaisawang P, Sirichoat A, Pannangrong W, Wigmore P, Welbat JU. Protective effects of melatonin against valproic acid-induced memory impairments and reductions in adult rat hippocampal neurogenesis. Neuroscience. 2019; 406: 580-593.
Naewla S, Sirichoat A, Pannangrong W, Chaisawang P, Wigmore P, Welbat JU. Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats. Nutrients. 2019; 11(4): 936.
Pannangrong W, Sirichoat A, Wongsiri T, Wigmore P, Welbat JU. Valproic acid withdrawal ameliorates impairments of hippocampal-spatial working memory and neurogenesis. J Zhejiang Univ-Sc B. 2019; 20: 253-263.